Elemental characteristics of sialoliths extracted from a patient with recurrent sialolithiasis

• 영문명: Elemental characteristics of sialoliths extracted from a patient with recurrent sialolithiasis
• 발행기관: 대한구강악안면외과학회
• 저자명: Buyanbileg Sodnom-Ish Mi Young Eo Kezia Rachellea Mustakim Yun Ju Cho Soung Min Kim
• 간행물 정보: 『대한구강악안면외과학회지』제50권 제2호, 94~102쪽, 전체 9쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2024.04.30

영문 초록

The exact mechanism of sialolith formation has yet to be determined. Recurrence of sialolithiasis is rare, affecting only 1%-10% of patients. The current study presents a case of recurrent stones that occurred twice on the right submandibular gland 6 months postoperative and 7 months after reoperation in a 48-year-old female patient. The stones were analyzed using histology, scanning electron microscopy, energy dispersive spectroscopy, and transmission electron microscopy (TEM). The first stone showed a three-layered structure with a poorly mineralized peripheral multilayered zone, highly mineralized middle layer, and the central nidus. The stones were composed of Ca, C, O, Cu, F, N, P, Si, Zn, and Zr. In TEM, compact bi-layered bacterial cell membrane was found on the peripheral layer and the central nidus of the stone as well as exosomes in the central nidus. The results demonstrated the essential components of sialolith formation, including bacteria, inflammatory exosomes, and exfoliated salivary epithelial cells that cooperatively underwent the pathogenetic progresses of central nidus formation, induction of compact zone calcification of the middle layer, and repeated subsequent deposition in the peripheral multilayer zone. The rapid recurrence could have resulted from residual pieces of a sialolith acting as the nidus of bacterial infection.

목차

I. Introduction

II. Case Report

III. Discussion

키워드

Sialolithiasis Salivary gland calculi Scanning electron microscopy Energy dispersive spectroscopy Transmission electron microscopy