Evidence-based clinical recommendations for hypofractionated radiotherapy: exploring efficacy and safety - Part 1. Brain and head and neck

• 영문명: Evidence-based clinical recommendations for hypofractionated radiotherapy: exploring efficacy and safety - Part 1. Brain and head and neck
• 발행기관: 대한방사선종양학회
• 저자명: Soo-Yoon Sung Jin Ho Song Byoung Hyuck Kim Yoo-Kang Kwak Kyung Su Kim Gyu Sang Yoo Hwa Kyung Byun Yeon Joo Kim Yeon-Sil Kim
• 간행물 정보: 『대한방사선종양학회지』제42권 제1호, 17~31쪽, 전체 15쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2024.03.30

영문 초록

Advances in radiotherapy (RT) techniques, including intensity-modulated RT and image-guided RT, have allowed hypofractionation, increasing the fraction size over the conventional dose of 1.8–2.0 Gy. Hypofractionation offers advantages such as shorter treatment times, improved compliance, and under specific conditions, particularly in tumors with a low α/β ratio, higher efficacy. It was initially explored for use in RT for prostate cancer and adjuvant RT for breast cancer, and its application has been extended to various other malignancies. Hypofractionated RT (HFRT) may also be effective in patients who are unable to undergo conventional treatment owing to poor performance status, comorbidities, or old age. The treatment of brain tumors with HFRT is relatively common because brain stereotactic radiosurgery has been performed for over two decades. However, re-irradiation of recurrent lesions and treatment of elderly or frail patients are areas under investigation. HFRT for head and neck cancer has not been widely used because of concerns regarding late toxicity. Thus, we aimed to provide a comprehensive summary of the current evidence for HFRT for brain tumors and head and neck cancer and to offer practical recommendations to clinicians faced with the challenge of choosing new treatment options.

목차

Introduction

Brain KQ1. What is the Optimal HFRT Schedule in Elderly Glioblastoma Patients?

Brain KQ2. What is the Optimal Indication and Schedule of HFRT in Meningioma?

Brain KQ3. Is HFRT Feasible for Brain Reirradiation in Recurrent Glioma?

Head and Neck KQ1. What is the Appropriate Hypofractionation Schedule for Elderly Frail Patients with Head and Neck Cancer?

Head and Neck KQ2. What are the Appropriate SBRT Schedules and Indications for Re-irradiation in Cases of Recurrent Head and Neck Cancer?

Conclusion

Statement of Ethics

Conflict of Interest

Funding

Author Contributions

Data Availability Statement

References

키워드

Hypofractionation Stereotactic body radiotherapy Brain neoplasms Meningioma Glioblastoma Head and neck neoplasms Frail elderly Re-irradiation