테크네슘 방사성의약품의 조제와 분배 과정에서 오염균에 대한 고찰

• 영문명: Consideration of a Bacteria Contamination Management in the Dispensation of ⁹⁹ᵐTc Radiopharmaceutical
• 발행기관: 대한핵의학기술학회
• 저자명: 최도철(Do Chul Choi) 김영수(Yeong Su Gim) 조광모(Gwang Mo Jo) 김희정(Hui Jeong Gim) 서한경(Han Gyeong Seo)
• 간행물 정보: 『핵의학기술』Vol.22 No.2, 84~87쪽, 전체 4쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2018.10.30

영문 초록

Purpose The radiopharmaceutical used in the nuclear medicine department is used only for the specific patient according to the prescription or instruction of the doctor without selling, so it is dispensed and it is distributed and used for the examination. Radiopharmaceuticals administered to patients should be managed appropriately as well as radiation safety management during dispensation. The purpose of this study is to investigate microbial contamination during dispensation of radiopharmaceuticals Materials and Methods This study distinguished between general workbench and clean workbench and performed three tests. First, microbial cultivation test of radiopharmaceutical prepared and dispensed in general workbenches and sterile workbenches were carried out five times, respectively. The second test was performed settle plate method three times before and after the use of the exhaust filter. Finally, Adenosine Triphosphate (ATP) measurement was performed in each workbench to measure bacterial counts. In addition, ATP measurement were carried out by designating locations and items that may be contaminated during dispensation. Results In the microbial culture test, no microorganisms were detected in both samples. In the settle plate method , it was detected without using of the exhaust filter in a general workbench once. In the ATP measurement test, it was measured at the level of 400 RLU or less, which is the standard value of contamination, in both workbenches surface. In additional ATP measurement test, the refrigerator handle in the distribution room was measured above the reference value of 1217 RLU, the vacuum vial shield of the Tech Generator at 435 RLU, and the syringe holder at 1357 RLU. After environmental disinfection, the results were reduced to 311 RLU, 136 RLU, and 291 RLU. Conclusion No contamination by bacteria was found in both workbenches. However, microbial contamination may occur if the use of an exhaust filter or proper hand hygiene is not achieved. Regular inspections and management for aseptic processing themselves will be necessary.

목차

서론

실험재료 및 방법

결과

결론 및 고찰

요약

REFERENCES

키워드

Radiopharmaceutical Workbench Bacteria Contamination ATP