[¹¹C]아세트산의 방사화학적 수율 증가를 위한 연구

• 영문명: Improvement of Radiosynthesis Yield of [¹¹C]acetate
• 발행기관: 대한핵의학기술학회
• 저자명: 박준영(Jun Young Park) 손정민(Jeongmin Son)
• 간행물 정보: 『핵의학기술』Vol.22 No.2, 74~78쪽, 전체 5쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2018.10.30

영문 초록

Purpose [¹¹C]acetate has been proved useful in detecting the myocardial oxygen metabolism and various malignancies including prostate cancer, hepatocellular carcinoma, renal cell carcinoma and brain tumors. The purpose of study was to improve the radiosynthesis yield of [¹¹C]acetate on a automated radiosynthesis module. Materials and Methods [¹¹C]acetate was prepared by carboxylation of grignard reagent, methylmagnesium chloride, with [¹¹C]CO₂ gas, followed by hydrolysis with 1 mM acetic acid and purification using solid phase extraction cartridges. The effect of the reaction temperature (0℃, 10℃, -55℃) and cyclotron beam time (10 min, 15 min, 20 min, 25 min) on the radiosynthesis yield were investigated in the [¹¹C]acetate labeling reaction. Results The maximum radiosynthesis yield was obtained at -10℃ of reaction temperature. The radioactivities of [¹¹C]acetate acquired at -10℃ reaction temperature was 2.4 times higher than those of [¹¹C]acetate acquired at -55℃. Radiosynthesis yield of [¹¹C]acetate increased with increasing cyclotron beam time. Conclusion This study shows that radiosynthesis yield of [¹¹C]acetate highly dependent on reaction temperature. The best radiosynthesis yield was obtained in reaction of grignard reagent with [¹¹C]CO₂ at -10℃. This radiolabeling conditions will be ideal for routine clinical application.

목차

서론

대상 및 방법

결과

고찰 및 결론

요약

REFERENCES

키워드

[¹¹C]Acetate Grignard reagent Hepatocellular carcinoma Radiopharmaceutical