뇌척수액에서 항 Glutamic acid decarboxylase 항체검사의 참고치 설정

• 영문명: Evaluation of reference value of anti-Glutamic acid decarboxylase antibody for cerebrospinal fluid
• 발행기관: 대한핵의학기술학회
• 저자명: 박민호(Min-Ho Park) 신선영(Sun-Young Shin) 윤태석(Tae-Seok Youn) 신희정(Hi-Jung Shin) 노경운(Gyeong-Woon Noh)
• 간행물 정보: 『핵의학기술』Vol.21 No.2, 28~30쪽, 전체 3쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2017.11.30

영문 초록

Purpose Anti-Glutamic acid decarboxylase antibody test (GAD Ab) has been used as a predictor of type 1 diabetes. GAD Ab has also been shown to be highly potent in cerebrospinal fluid (CSF) of patients with suspected diabetic peripheral neuropathy. Recently, it has been known that clinical significance of GAD Ab using CSF is useful for the neurological disorders. However, the reference value of anti-GAD Ab has been provided only for serum. In this experiment, we estimated the reference value of anti-GAD antibody for CSF in neurological patients. Materials and Methods A total of 211 neurological patients were enrolled. Serum and CSF were analyzed by radioimmunoassay (RIA) using commercial RIA anti-GAD Ab kit (RSR, London, United Kingdom). Normal saline was used as the normal CSF control because CSF is most similar to 0.9% normal saline. Results The mean value of normal CSF control was 1.97 U/mL, and two standard deviations (2SD) was 1.44 U/mL. Based on this data, the expected reference range of CSF could be estimated from 0.54 U/mL to 3.40 U/mL Conclusion The reference range of normal CSF control using normal saline obtained with Hoffmann's method. However, there will be a need to validate the CSF reference values using human normal CSF.

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키워드

Glutamic Acid Decarboxylase Antibody (GAD Ab) Cerebrospinal fluid (CSF) Radioimmunoassay (RIA)