방사성 의약품 자동 분주장치의 유용성 및 최적화된 분주방법에 관한 고찰

• 영문명: A Study on the Usefulness of Auto Dispenser and Optimized Dispensing Method
• 발행기관: 대한핵의학기술학회
• 저자명: 이정은(JeoungEun Lee) 김호성(Hosung Kim) 류재광(Jaekwang Ryu) 정우영(Wooyoung Jung)
• 간행물 정보: 『핵의학기술』Vol.17 No.2, 59~66쪽, 전체 8쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2013.11.30

영문 초록

Purpose: Recently, there is an increase of the number of hospitals using auto dispenser to reduce occupational radiation exposure when drawing up of the ¹⁸F-FDG dose (5.18 MBq/kg) in a syringe from the dramatic high activity of ¹⁸F-FDG multidose vial. The aim of this study is to confirm that using auto dispenser actually reduces the radiation exposure for technologists. Also we analyzed the reproducibility of auto dispenser to find optimized dispensing method for the device. Materials and Methods: We conducted three experiments. Comparison of radiation exposure on chest and hands: The chest and hands exposure dose received by technologists during the injection were measured by electronic personal dosimeter (EPD) and ring TLD respectively. Reproducibility of dispensed volume: We draw up the normal saline into 5 and 2 mL syringe using auto dispenser by changing the volume from 1 to 15 mm for 5 times in the same setting of the volume. The weight of 5 normal saline dispensed from the device at same volume was measured using micro balance and calculated standard deviation and coefficient of variation. Reproducibility of dispensed radioactivity: We dispensed 362.6 MBq±10%of ¹⁸F-FDG in 5 and 2 mL syringes from the multidose vial of different specific activity. In the same setting of volume, we repeated dispensing for 4 times and compared standard deviation and coefficient of variation of radioactivity between 5 syringes. Results: There was significant difference in the average of chest exposure dose according to the dispensing methods (P<0.05). Also, when dispensing ¹⁸F-FDG in manual method, exposure dose was 11.5 times higher in right hand and 4.8 times higher in left hand than in auto method. In the result of reproducibility of dispensed volume, standard deviation and coefficient of variation shows decline as the dispensing volume increases. As a result of reproducibility of dispensed radioactivity, standard deviation and coefficient of variation increases as the specific activity increases. Conclusion: We approved that the occupational radiation exposure dose of technologists were reduced when dispensing ¹⁸F-FDG using auto dose dispenser. Secondly, using small syringes helps to increase reproducibility of auto dose dispense. And also, if you lower the specific activity of ¹⁸F-FDG in multidose vial below 915-1,020 MBq/mL, you can use auto dispenser more effectively keeping the coefficient of variation lower than 10%.

목차

서론

실험재료 및 방법

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REFERENCES

키워드

Auto dispenser Radiation exposure Specific activity (MBq/mL)