(n,γ)⁹⁹Mo를 이용한 ⁹⁹Mo-99mTc발생기의 유용성 평가

• 영문명: The Evaluation of Usefulness of ⁹⁹Mo-99mTc Generator Using(n,γ)⁹⁹Mo Developed by Korea Atomic Energy Research Institute
• 발행기관: 대한핵의학기술학회
• 저자명: 서한경(Han Kyung Seo) 김정호(Jeong Ho Kim) 심철민(Cheol Min Shim) 김병철(Byung Cheol Kim) 최도철(Do Cheol Choi) 권용주(Yong Ju Gwon) 박영순(Yung Sun Park) 김동윤(Dong Yun Kim)
• 간행물 정보: 『핵의학기술』Vol.17 No.2, 48~52쪽, 전체 5쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2013.11.30

영문 초록

Purpose: The Molybdenum which is the raw material of ⁹⁹Mo-⁹⁹ᵐTc generator is produced from the nuclear reactor. However, output has dwindled as the two nuclear reactors supplying the bulk of radioactive material-one in Chalk River, Ontario and the other in Petten, the Netherlands-have been closed for repairs or maintenance. This resulted in the enhancement of its price. So ⁹⁹Mo-⁹⁹ᵐTc generator using(n,γ)⁹⁹Mo is developed by Korea Atomic Energy Research Institute (KAERI). Medicinal availability of this generator is evaluated in this study. Materials and Methods: The radioactivity of ⁹⁹ᵐTc eluted in generator 1, 2 and 3 unit developed by KAERI was measured. The quality control test of generator such as appearance test, pH test, LAL test, sterility test, chemical impurity (Al) test and radiochemical purity test were performed. Planar and SPECT/CT image sof SD rat (6 weeks, Female) at 2 hr after injection of ⁹⁹ᵐTc-HDP (hydroxymethylenediphosphonate) (TechneScan HDP, Malinckrodt Medical, Dutch) and ⁹⁹ᵐTc-DPD (diphosphono-1, 2-propanedicarboxylicacid) (TECEOS, CIS bio international, France) which were labeled with ⁹⁹ᵐTc eluted in KAERI and commercial generator (40.5 GBq, Malinckrodt Medical, Dutch) using SPECT/CT camera (Symbia, Siemense, Germany) were obtained respectively. Results: The mean radioactivity of ⁹⁹ᵐTc elution generator 1unit was 4.18 GBq (113 mCi), generator 2 unit was 4.73 GBq (128 mCi) and generator 3 unit was 3.33 GBq (90 mCi). All quality control tests were within normal limit except pyrogentest. Pyrogen test was positive. Planar and SPECT/CT images of rat injected ⁹⁹ᵐTc-HDP which was labeled with ⁹⁹ᵐTc eluted in commercial generator show increased uptake in bone, stomach and bowl. Planar images show increased uptake in liver and bone in case of ⁹⁹ᵐTc-DPD. However, images of rat injected ⁹⁹ᵐTc-HDP and ⁹⁹ᵐTc-DPD which were labelled ⁹⁹ᵐTc eluted in KAERI generator show increased uptake in bone, liver and spleen. Conclusion: If shortcoming is removed such as pyrogen and liver appearance, domestic role as an alternative generator is thought to be able to fill and to secure the national medical service by supplying ⁹⁹ᵐTc when the supply of ⁹⁹ᵐTc be comes short.

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키워드

Korea Atomic Energy Research Institute (KAERI) generator (n,γ)⁹⁹Mo Quality control