조영증강 18F-FDG PET/CT가 이중에너지 X-선 흡수 계측법을 이용한 골밀도 및 체성분 측정에 미치는 영향

• 영문명: Effect of Contrast-Enhanced 18F-FDG PET/CT on Measurements of Whole Body Bone Mineral Density and Body Composition by Dual-Energy X-Ray Absorptiometry
• 발행기관: 대한핵의학기술학회
• 저자명: 김성수(Seong Su Kim) 이선도(Sun Do Lee) 이남주(Nam Ju Lee) 신용철(Yong Cheol Shin) 모은희(Eun Hee Mo) 이춘호(Chun Ho Lee)
• 간행물 정보: 『핵의학기술』Vol.16 No.2, 7~11쪽, 전체 5쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2012.10.30

영문 초록

Purpose : The effect of concomitant use of 18F-FDG and intravenous contrast agent (CA) on dual-energy X-ray absorptiometry (DXA), was rarely reported. We had investigated these potentially confounding effects. Materials and Methods : Twenty-two patients had undergone DXA before and immediately after 18F-FDG PET/CT scans. Two DXA and 1 PET/CT scans had performed within one-day. 18F-FDG PET/CT scans had been performed with CA in 17 patients and without CA in 5 patients. Whole body bone mineral content (BMC), whole body bone mineral density (BMD), total fat mass (TFM), and lean body mass (LBM) were measured by DXA scanner before and after the 18F-FDG PET/CT scans. Results : BMC, BMD, TFM and LBM had significantly affected by 18F-FDG PET/CT with CA (BMC, +13.7%, from 2061.3±393.7 to 2343.4±373.3; BMD, +9.3%, from 1.07±0.09 to 1.17±0.08; TFM, -34.1%, from 17052.1±4049.9 to 11237.1±2990.3; LBM, +13.6%, from 45834.5±5662.1 to 52094.0±6335.4). However, 18F-FDG PET/CT without CA had no effect on the measurement of DXA (BMC, +2.4%, from 2197.7±391.6 to 2251.5±380.9; BMD, +1.8%, from 1.13±0.09 to 1.15±0.07; TFM, -6.8%, from 14585.6±3455.9 to 13591.3±4351.4; LBM, +2.2%, from 47360.5±8381.8 to 48441.1±8488.1). Conclusion : The measurements of DXA are affected by using CA. However, DXA scans might be unaffected by the presence of 18F-FDG administered for PET/CT.

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실험재료 및 방법

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키워드

Contrast Enhancement Dual-Energy X-Ray Absorptiometry PET/CT Bone Mineral Density