갑상선암의 경부 림프절 전이 진단을 위한 미세침세척액 티로글로불린 측정법

• 영문명: Thyroglobulin Measurement in Fine Needle Aspirates for Diagnosing Cervical Lymphnode Metastasis from Differentiated Thyroid Malignancy
• 발행기관: 대한핵의학기술학회
• 저자명: 고희영(Hee Young Ko) 김승수(Seung Su Kim) 이춘호(Chun Ho Lee)
• 간행물 정보: 『핵의학기술』Vol.14 No.2, 181~185쪽, 전체 5쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2010.10.30

영문 초록

Purpose: Several studies report that detection of thyroglobulin (Tg) in fine-needle aspiration (FNA) biopsy washout fluid from lymph nodes identifies recurrences or metastases of differentiated papillary thyroid cancer (DPTC) in the neck with higher sensitivity and specificity than fine-needle aspiration cytology (FNAC). We evaluate the diagnostic efficacy and usefulness of Tg measurement in FNA washout fluid (FNA-Tg) and compare with FNAC. Materials and Methods: Forty-eight FNA samples of 37 patients who undergone ultrasonography to detect cervical lymph node metastasis of DPTC, were included for this study. Lymph node metastasis was confirmed by histopathologic examination or long-term imaging follow-up. Sensitivity, specificity and accuracy of FNA-Tg and FNAC were calculated. In 34 patients, we evaluated diagnostic accuracy of FNA-Tg according to the presence or absence of Tg antibody. Results: Sensitivity, specificity and accuracy of FNAC were 75.0%, 97.2% and 91.7%, respectively, and those of FNA-Tg were 100%, 88.9% and 91.7%, respectively. The presence of Tg antibody was not relevant to the diagnostic accuracy of FNA-Tg. Conclusion: FNA-Tg is a as accurate as FNAC with higher sensitivity. FNA-Tg and FNAC are complement techniques for diagnosing lymph node metastasis of DTPC.

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실험재료 및 방법

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키워드

Differentiated papillary thyroid cancer Fine-needle aspiration Thyroglobulin Washout fluid