⁹⁹ᵐTc 발생기의 24시간 내 2회 용출의 유용성 평가

• 영문명: The Evaluation of Usefulness of Two Times Elution a Day of ⁹⁹ᵐTc Using ⁹⁹ᵐo-⁹⁹ᵐTc Generator
• 발행기관: 대한핵의학기술학회
• 저자명: 김정호(Jeong Ho Kim) 서한경(Han Kyung Seo) 정영환(Yeong Hwan Jeong) 김영수(Yeong Su Kim) 김병철(Byung Cheol Kim) 권용주(Yong Ju Gwon) 이정옥(Jeong Ok Lee) 박영순(Yeong Sun Park) 김동윤(Dong Yun Kim)
• 간행물 정보: 『핵의학기술』Vol.14 No.2, 83~86쪽, 전체 4쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2010.10.30

영문 초록

Purpose: The Molybdenum which is the raw material of ⁹⁹ᵐo-⁹⁹ᵐTc generator (generator) is produced from the nuclear reactor. However, output has dwindled as the two nuclear reactors supplying the bulk of radioactive material-one in Chalk River, Ontario and the other in Petten, the Netherlands-have been closed for repairs or maintenance. This resulted in the enhancement of its price. Therefore we have tried to seek the new method which could run generator to increase activity of ⁹⁹ᵐTc in this study. Materials and Methods: The ⁹⁹ᵐTc activity obtained from 5 times elution for 5 days from Monday to Friday using two generators was compared with 10 times elution. Appearance test, pH test, LAL test, sterility test, chemical impurity(Al) test, radio chemical purity test, ratio of ⁹⁹ᵐo/⁹⁹ᵐTc activity test have been done to check the stability of ⁹⁹ᵐTc eluting from generator respectively. Results: The ⁹⁹ᵐTc activity obtained from 5 times elution for 5 days was 168.2 GBq (4545 mCi) and 10 times was 230.5 GBq (6230 mCi). All quality control tests were within normal limit. Conclusion: We got to know that 2 times elution a day obtained more ⁹⁹ᵐTc activity than one time elution in this study.

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실험재료 및 방법

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키워드

⁹⁹ᵐo-⁹⁹ᵐTc Generator ⁹⁹ᵐTc