통계적 분석을 통한 Insulin의 정상 참고치 설정

• 영문명: Establishment of Reference Value of Insulin Using the Statistical Analysis
• 발행기관: 대한핵의학기술학회
• 저자명: 김외정(Whe Jung Kim) 윤필영(Pil Young Yoon) 신영균(Young Goon Shin) 유선희(Seon Hee Yoo) 조시만(Shee Man Cho)
• 간행물 정보: 『핵의학기술』Vol.14 No.1, 143~146쪽, 전체 4쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2010.06.30

영문 초록

Purpose: Insulin is involved in carbohydrate metabolism and also it’s very important because it increases storage of glycogen, synthesis of fatty acids, absorption of amino acid, synthesis of protein. Insulin is clinically useful when we evaluate fasting patients in hypoglycemia, classify and predict diabetes, assess the activity of β-cell, research insulin resistance. We are going to increase usability of insulin assay by establishing normal reference value according to statistical analysis. Material & Method: We selected 6,648 patients who visited asan health medical center from May to August in 2008. We set exclusion criteria as family of diabetes, diabetes medication, the past history of blood glucose rise, more than 100 mg/dL in normal fasting blood glucose, outside the scope of BMI 18.5~22.9 kg/m², and more than HbA1c 6.5%. We determine whether the subgroup is portioned as sex and age or not and establish normal reference value by conducting statistical analysis as Bayesian’s method and Hoffman’s method. Result: Portioning of subgroup as sex and age is not needed. By statistical analysis of Bayesian method, results 1.5‐11.0 uIU/mL. By statistical analysis of Hoffman method, results 1.8~12.8 uIU/mL. Conclusion: We established 1.8~12.8 uIU/mL as Insulin normal reference value by Hoffman method. This is a similar value with reporting reference value 1.7~11.8 uIU/mL in kit. This will enhance the usability of insulin assay by establishing normal reference value.

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키워드

Insulin 정상 참고치 Bayesian 법 Hoffmann 법