전신 뼈 스캔 후 경과 시간 차이에 따른 ²⁰¹Tl 심근관류 SPECT 영상의 영향 평가

• 영문명: The Influence Evaluation of ²⁰¹Tl Myocardial Perfusion SPECT Image According to the Elapsed Time Difference after the Whole Body Bone Scan
• 발행기관: 대한핵의학기술학회
• 저자명: 김동석(Dong Seok Kim) 유희재(Hee Jae Yoo) 류재광(Jae Kwang Ryu) 유재숙(Jae Sook Yoo)
• 간행물 정보: 『핵의학기술』Vol.14 No.1, 67~72쪽, 전체 6쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2010.06.30

영문 초록

Purpose: In Asan Medical Center we perform myocardial perfusion SPECT to evaluate cardiac event risk level for non-cardiac surgery patients. In case of patients with cancer, we check tumor metastasis using whole body bone scan and whole body PET scan and then perform myocardial perfusion SPECT to reduce unnecessary exam. In case of short term in patients, we perform ²⁰¹Tl myocardial perfusion SPECT after whole body bone scan a minimum 16 hours in order to reduce hospitalization period but it is still the actual condition in which the evaluation about the affect of the crosstalk contamination due to the each other dissimilar isotope administration doesn’t properly realize. So in our experiments, we try to evaluate crosstalk contamination influence on ²⁰¹Tl myocardial perfusion SPECT using anthropomorphic torso phantom and patient’s data. Materials and Methods: From 2009 August to September, we analyzed 87 patients with ²⁰¹Tl myocardial perfusion SPECT. According to ²⁰¹Tl myocardial perfusion SPECT yesterday whole body bone scan possibility of carrying out, a patient was classified. The image data are obtained by using the dual energy window in ²⁰¹Tl myocardial perfusion SPECT. We analyzed ²⁰¹Tl and ⁹⁹ᵐTc counts ratio in each patients groups obtained image data. We utilized anthropomorphic torso phantom in our experiment and administrated ²⁰¹Tl 14.8 MBq (0.4 mCi) at myocardium and ⁹⁹ᵐTc 44.4 MBq (1.2 mCi) at extracardiac region. We obtained image by ²⁰¹Tl myocardial perfusion SPECT without gate method application and analyzed spatial resolution using Xeleris ver 2.0551. Results: In case of ²⁰¹Tl window and the counts rate comparison result yesterday whole body bone scan of being counted in ⁹⁹ᵐTc window, the difference in which a rate to 24 hours exponential-functionally notes in 1:0.114 with Ventri (GE Healthcare, Wisconsin, USA), 1:0.249 after the bone tracer injection in 12 hours in 1:0.411 with 1:0.79 with Infinia (GE healthcare, Wisconsin, USA) according to a reduction a time-out was shown (Ventri p=0.001, Infinia p=0.001). Moreover, the rate of the case in which it doesn’t perform the whole body bone scan showed up as the average 1:0.067±0.6 of Ventri, and 1:0.063±0.7 of Infinia. According to the phantom after experiment spatial resolution measurement result, and an addition or no and time-out of ⁹⁹ᵐTc administrated, it doesn’t note any change of FWHM (p=0.134). Conclusion: Through the experiments using anthropomorphic torso phantom and patients data, we found that ²⁰¹Tl myocardium perfusion SPECT image later carried out after the bone tracer injection with 16 hours this confirmed that it doesn’t receive notable influence in spatial resolution by ⁹⁹ᵐTc. But this investigation is only aimed to image quality, so it needs more investigation in patient’s radiation dose and exam accuracy and precision. The exact guideline presentation about the exam interval should be made of the validation test which is exact and in which it is standardized about the affect of the crosstalk contamination according to the isotope use in which it is different later on.

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키워드

Crosstalk contamination Myocardial perfusion SPECT ²⁰¹Tl