전립선암 환자의 뼈 전이에 대한 ¹⁸F-Fluoride PET/CT의 유용성

• 영문명: Usefulness of ¹⁸F-Fluoride PET/CT in Bone Metastasis of Prostate Cancer
• 발행기관: 대한핵의학기술학회
• 저자명: 박민수(Min Soo Park) 김정열(Jung Yul Kim) 박훈희(Hoon Hee Park) 강천구(Chun Goo Kang) 임한상(Han Sang Lim) 김재삼(Jae Sam Kim) 이창호(Chang Ho Lee)
• 간행물 정보: 『핵의학기술』Vol.13 No.2, 24~30쪽, 전체 7쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2009.10.30

영문 초록

Purpose: Today, Prostate cancer has been gradually increasing, according to the change of internal incidence rate of cancer. Generally, prostate cancer has lead to dead over 90%, in case of metastasis of lymph node and bone. So, innovative development of new radiopharmaceutical and imaging modality is progressed for detection of that metastasis, in nuclear medicine, now. Therefore, this study shows the usefulness of ¹⁸F-Fluoride PET/CT improved diagnosability on bone metastasis of prostate cancer. Materials and Methods: In this study, 33 male patients with prostate cancer were examined (The mean age: 67.8±10.2 years old). Every patient was done each whole body bone scan (WBBS) and ¹⁸F-Fluoride positron emission tomography/computed tomography (¹⁸F-Fluoride PET/CT). And then, using Receiver Operating Characteristic Curve (ROC curve), each sensitivity and specificity of two modalities was measured and compared with. Results: In 22 patients (66.6%) of all, bone metastasis was detected. And, in WBBS, sensitivity was 63.6%, specificity, 81.8%; in ¹⁸F-Fluoride PET/CT, sensitivity was 100% and specificity was 90.9%. As a result of ROC curve, AUROC (The Area under an ROC) of WBBS was 0.778, and that of ¹⁸F-Fluoride PET/CT, 0.942. Conclusions: ¹⁸F-Fluoride PET/CT was higher both sensitivity and specificity than WBBS, and it was valuable to detect bone metastasis of prostate cancer more definitely, with 3D imaging realization. Also, in ¹⁸F-Fluoride PET/CT, physiological images were acquired in more short time than WBBS, so, it was possible to reduce patient’s waiting time and complaint. Therefore, it is considered that ¹⁸F-Fluoride PET/CT is able to improve diagnosability by offering more accurate images, as cuts in a share of high cost.

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¹⁸F-Fluoride PET/CT Prostate cancer Bone metastasis