Resective Epilepsy Surgery after Corpus Callosotomy in Children with Lennox-Gastaut Syndrome

• 영문명: Resective Epilepsy Surgery after Corpus Callosotomy in Children with Lennox-Gastaut Syndrome
• 발행기관: 대한소아신경학회
• 저자명: Soyoung Park Hye Eun Kwon Chung Mo Koo Yun Jung Hur Hoon-Chul Kang Joon Soo Lee Heung Dong Kim
• 간행물 정보: 『Annals of Child Neurology(구 대한소아신경학회지)』vol.32 no.1, 13~20쪽, 전체 8쪽
• 주제분류: 의약학 > 소아과학
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

Purpose: This study examined the characteristics and outcomes of resective epilepsy surgery following corpus callosotomy (CC) in children with Lennox-Gastaut syndrome (LGS). Methods: We retrospectively analyzed 17 children with LGS who underwent resective surgery (RS) after CC over a span of 10 years, with a minimum of 2 years of follow-up, at a single tertiary epilepsy center in Korea. Results: Of the 17 patients, 13 (73.5%) demonstrated favorable surgical outcomes (Engel class I or II) at 1 year after RS, and eight (47.1%) were ultimately free of seizures 2 years after surgery. A significantly larger decrease in the number of anti-seizure medications taken from before to 2 years after the final surgical procedure was observed in the group that became seizure-free than in the group with persistent seizures (P=0.062). Furthermore, a significantly greater decline in daily adaptive function was found in the persistent seizure group (P=0.059). The baseline characteristics, results of presurgical evaluation, and treatment-related factors assessed prior to surgery showed no significant differences between the seizure-free group and the group with persistent seizures. Conclusion: In conclusion, RS may be a viable option for patients with LGS who exhibit lateralization and/or localization on presurgical evaluation after CC, as the procedure may reveal a concealed primary focus. The proactive implementation of two-stage epilepsy surgery could provide significant seizure reduction and preservation of cognitive function in carefully selected patients with LGS.

목차

Introduction

Materials and Methods

Results

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키워드

Child Lennox Gastaut syndrome Seizures