흰 쥐의 만성 통증모델에서 구강건조증이 c-fos 발현에 미치는 영향

• 영문명: Effects of Xerostomia on C-Fos Expression in a Chronic Pain Model in Rats
• 발행기관: 한국구강보건과학회
• 저자명: 김유미 박민경 최자형 조민정 이민경
• 간행물 정보: 『한국구강보건과학회지』제11권 제4호, 91~97쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

Objectives: The purpose of this study was to determine whether xerostomia could improve the level of neuropathic pain. To conduct the study, the change in c-fos expression level in the medulla oblongata was confirmed by xerostomia induction using the chronic neuropathic facial pain model. Methods: mal-positioned dental implant surgery was performed on the extraction site of the mandibular second molar of rats, and 4-diphenylacetoxy-N- methylpiperidine (4-DAMP) (30mg/kg) was injected intraperitoneally after a pain test on the 4th day after surgery. c-fos was counted only in the lamina I and II regions. Results: A significant increase in c-fos expression was observed when the maxilla was stimulated compared to the mandible in the group induced both neuropathy and xerostomia. Conclusions: Therefore, it is considered that xerostomia in the facial area is the cause of the expression of chronic pain and the improvement of pain sensation.

목차

Ⅰ. 서론

Ⅱ. 연구방법

Ⅲ. 연구결과

Ⅳ. 고찰

Ⅴ. 결론

참고문헌

키워드

c-fos medulla oblongata neuropathic pain rat xerostomia