L-Lysine을 이용하여 가용화한 페오니플로린 난소 흡수율 및 생체 이용률 연구

• 영문명: Ovarian Absorption and Systemic Bioavailability Study of Paeoniflorin Solubilized with L-Lysine
• 발행기관: 대한약학회
• 저자명: 황예진(Ye Jin Hwang) 김아름(Ah Rum Kim) 김현우(Hyeon Woo Kim) 강재선(Jae Seon Kang)
• 간행물 정보: 『약학회지』제67권 제6호(2023년), 372~377쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

Menopause refers to the period in a woman’s life when ovarian function declines, leading to a cessation of ovulation and a significant hormonal shift. Commonly associated symptoms include facial flushing, sleep disturbances, fatigue, and depression. These symptoms are typically treated with hormone therapy, although there is concern about the increased risk of endometrial cancer, cardiovascular disease, and breast cancer associated with excessive estrogen use. This has led to a growing interest in natural remedies as an alternative approach. Paeoniflorin is a pharmacologically active compound found in Paeonia lactiflora, one of the major components of this plant. Paeonia lactiflora has been traditionally used to treat women’s health issues, but there is currently insufficient research in this area compared to its historical use. Moreover, there is a lack of studies on ovarian absorption rates, prompting the present study. In this research, paeoniflorin was solubilized using L-Lysine, and its ovarian absorption rate and overall bioavailability were compared to the conventional extract. The results demonstrated a 58.5% increase in ovarian absorption when solubilized with L-Lysine. In terms of overall bioavailability, the area under the curve (AUC) value for oral administration was 3122.66 ng·hr/mL, whereas the AUC value for intravenous injection was 4191.20 ng·hr/mL. These findings suggest the potential of L-Lysinesolubilized paeoniflorin as an effective treatment for menopausal symptoms, offering a promising natural alternative to hormone therapy.

목차

서 론(Introduction)

방 법(Methods)

결과 및 고찰(Results and Discussion)

결 론(Conclusion)

감사의 말씀(Acknowledgment)

Conflict of Interest

References

키워드

L-Lysine Menopause Oral administration Ovary Paeoniflorin