동물모델을 이용한 병풀의 항아토피 효능 평가

• 영문명: Evaluation of Anti-atopic Efficacy of Centella asiatica using Animal Model
• 발행기관: 대한약학회
• 저자명: 배재필(Jae Pil Bae) Venkata Prakash Annamneedi 박준우(Jun Woo Park) 박진홍(Jin Hong Park) 박영민(Youngmin Park) 이기만(Kiman Lee) 강태진(Tae Jin Kang)
• 간행물 정보: 『약학회지』제67권 제6호(2023년), 354~359쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

Centella asiatica (C. asiatica) is currently widely used in wound healing and has recently been reported to have immune suppressive properties. Atopic dermatitis (AD) is a chronic inflammatory and allergic disease. We herein investigated the anti-atopic effect of C. asiatica in vivo. To examine the anti-atopic dermatitis activity of C. asiatica the ovalbumin-induced BALB/c mouse model was used. Ovalbumin mixture was injected into the abdominal cavity and patched on the back to induce AD, and then treated by orally administering C. asiatica. C. asiatica reduced major signs of clinical skin severity such as erythema, pruritus, lichenification, edema/escoriations, and dryness. A decrease in the number of scratch was also seen in scratching counts. The level of serum IgE was also reduced in mice treated with C. asiatica. We therefore suggested C. asiatica extract can be used as a therapeutic agent for AD treatment.

목차

서 론(Introduction)

방 법(Methods)

결 과(Results)

고 찰(Discussion)

결 론(Conclusion)

감사의 말씀(Acknowledgment)

Conflict of Interest

References

키워드

Centella asiatica Atopic dermatitis in vivo IgE