망막 혈관 질환에서 원형 RNA의 작용 기전 및 RNA 치료제로서의 가능성

• 영문명: Mechanism of Circular RNAs and Their Potential as Novel Therapeutic Agents in Retinal Vascular Diseases
• 발행기관: 대한약학회
• 저자명: 김현종(Hyunjong Kim) 류주희(Juhee Ryu)
• 간행물 정보: 『약학회지』제67권 제6호(2023년), 325~334쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

Maintaining and preserving visual function became critical in this aging society. The number of patients with retinal vascular disease such as retinopathy of prematurity, age-related macular degeneration, and diabetic retinopathy is gradually increasing due to increased life expectancy, advancements in the technology of delivering premature babies, and complications due to eating habits. To treat these retinal vascular diseases, surgical intervention such as laser photocoagulation and anti-vascular endothelial growth factor (VEGF) drugs can be considered. However, these treatment options are accompanied by various complications and adverse effects. Thus, new treatments focusing on the pathogenesis of retinal vascular disease need to be developed. Various evidences suggest that circular RNA is involved in the pathogenesis of retinal disease. In this article, we discuss about currently used treatments of retinal vascular diseases and the emerging role of circular RNAs in the pathogenesis of retinal vascular diseases. Therefore, understanding the mechanism of circular RNA regulating retinal disease and developing therapeutics using these circular RNAs may offer novel treatment options to cure retinal vascular disease.

목차

서 론(Introduction)

원형 RNA를 이용한 망막혈관질환 연구

망막 질환 진단 및 치료를 위한 원형 RNA 활용 가능성

결 론(Conclusion)

감사의 말씀(Acknowledgment)

Conflict of Interest

References

키워드

Retinal vascular disease Angiogenesis Retinopathy of prematurity Diabetic retinopathy Age-related macular degeneration MicroRNA Circular RNA