Optimization of novel type of trivalent inactivated Salmonella bacterial vaccine prevention program against Salmonella infections in poultry

• 영문명: Optimization of novel type of trivalent inactivated Salmonella bacterial vaccine prevention program against Salmonella infections in poultry
• 발행기관: 한국예방수의학회
• 저자명: Yeong Ju Yu Jeong Hee Yu Jin Hur
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.47, No.4, 190~197쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

The optimization of a prevention program utilizing a novel trivalent inactivated Salmonella bacterial vaccine to protect poultry from Salmonella infections was evaluated in this study. A total of 50 brown nick layers were divided into 5 groups, A to E, each containing 10 hens. Group B hens were immunized with the SG9R vaccine, group C chickens were immunized with the trivalent inactivated Salmonella bacterial vaccine, and group D hens were primed with SG9R and boosted with the trivalent inactivated Salmonella bacterial vaccine. Group E hens were injected with sterile PBS. All hens in groups B to E were orally challenged with a mixture of wild-type S. Enteritidis, S. Typhimurium, and S. Gallinarum (approximately 6×10⁹ CFU/ 0.2 ml/bird). Serum IgG titers, CD3+CD4+ T-cell levels, and CD3+CD8+ T-cell levels in group D were significantly higher than those in group A. Additionally, all animals in groups A to D showed no clinical symptoms and survived after the virulent challenges, whereas all chickens in group E died following the challenge. The challenge strains of S. Enteritidis, S. Typhimurium, and S. Gallinarum were not isolated from the liver, spleen, cecum, and cloaca of group D chickens. These findings indicate that priming with SG9R and boosting with a trivalent inactivated Salmonella bacterial vaccine can be an effective approach for preventing Salmonella infections by inducing robust protective humoral and cellular immune responses in chickens.

목차

서 론

재료 및 방법

결 과

고 찰

감사의 글

REFERENCES

키워드

Salmonella infections Zoonosis Poultry Trivalent inactivated Salmonella bacterial vaccine Optimization