Effect of weakly acidic hypochlorous acid water on the treatment of murine dermatitis infected with Microsporum canis

• 영문명: Effect of weakly acidic hypochlorous acid water on the treatment of murine dermatitis infected with Microsporum canis
• 발행기관: 한국예방수의학회
• 저자명: Chun-Nam Cha Yeung-Bae Jin Kwang-Il Park Woo H. Kim Suk Kim Jin-Kyung Kim Hu-Jang Lee
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.47, No.4, 165~170쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.12.31

영문 초록

This study evaluated the fungicidal efficacy of weakly acidic hypochlorous acid water (WAHW) against Microsporum canis (M. canis) and its therapeutic effect on M. canis-infected mouse skin. WAHW was produced by a WAHW generation module. A fungicidal efficacy test by the broth dilution method was used to determine the lowest effective concentration of the WAHW. The lowest effective concentration of WAHW was less than 10 ppm. For T-1, T-2, and T-3, 30 ppm of WAHW was applied to the infected skin once, twice, and three times a day, respectively, and for T-4, 50 ppm of WAHW was applied once a day. On the 3rd day after the initiation of treatment, skin scores in all of the WAHW-treated groups were significantly decreased compared to those in the positive control group (PC) (p<0.05), and there were no significant differences compared to the normal control (NC). The area of the infected skin in all of the WAHW-treated groups was significantly decreased compared to PC from the first day after the initiation of WAHW treatment (p<0.05). The results showed that WAHW had a fungicidal efficacy on M. canis at less than 10 ppm, and it was effective in improving skin symptoms when 30 ppm of WAHW was applied to the M. canis-infected area once a day for five days or 50 ppm of WAHW was applied once a day.

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Weakly acidic hypochlorous acid water Microsporum canis Zoonophilic dermatophytes Fungicidal efficacy Mice