고무풍선 중 니트로스아민류의 노출평가 연구

• 영문명: Oral Exposure Assessment of N-Nitrosamines from Rubber Balloons in Korea
• 발행기관: 한국환경보건학회
• 저자명: 김현경(Hyunkyung Kim) 이기영(Kiyoung Lee)
• 간행물 정보: 『한국환경보건학회지』제49권 제4호, 210~217쪽, 전체 8쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2023.08.31

영문 초록

Background: N-nitrosamines are carcinogenic substances often found in rubber products. They are produced when certain additives of rubber products react with nitrite in saliva or air. Exposure assessment for the proper management and communication of N-nitrosamines in rubber balloons should be carried out. Objectives: This study was conducted to determine the concentrations of N-nitrosamines in rubber balloons in the South Korean market and assess exposure among Korean children. Methods: Forty eight rubber balloon products in the domestic market were purchased and a total of 68 balloons were analyzed for N-nitrosamines and N-nitrosatable substances. Chemical analysis was conducted by HPLC-MS/MS according to the method EN 71-12. For exposure assessment, an exposure algorithm and coefficients were obtained from previous studies. Results: Among the 68 rubber balloons, N-nitrosamines were detected in 18 (26.5%) with an average level of 60.77 μg/kg. N-Nitrosatable substances were detected in 44 products (64.7%) with an average level of 1353.33 μg/kg. As a result of the exposure evaluation, the exposure dose differed according to how exposure coefficients were applied. The median exposure (50th percentile) was higher in the age group of 6~12 years, and high exposure (95th percentile) was higher in the age group of 13~18. Conclusions: We evaluated the N-nitrosamines contained in rubber balloons purchased in the domestic market and assessed oral exposure among South Korean children. For integrated risk management of N-nitrosamines, further studies and discussion regarding exposure and risk assessment are required.

키워드

Children’s products oral exposure exposure assessment N-nitrosamines rubber balloons