Genuine traditional Korean medicine, BaekJeol-Tang for the treatment of rheumatoid arthritis

• 발행기관: 셀메드 세포교정의약학회
• 저자명: Na-Ra Han Woo-Moon Sim Moo-Chang Sul Min-Cheol Kim Chang-Hee Lee Dong- Won Kim Se-Hun Lee 외 12명
• 간행물 정보: 『셀메드』Volume 3 Issue 2, 1~7쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2013.05.31

영문 초록

Inflammation in rheumatoid arthritis is characterized by immune cell infiltration and cytokine secretion. In particular, mast cells and their cytokines play an important role in the pathogenesis of rheumatoid arthritis. Korean medicine, BaekJeol-Tang (BT) was designed by traditional Korean medicine theory. We already reported therapeutic effect of BT in rheumatoid arthritis. Here, we report the specific underlying mechanism of BT in activated human mast cells, HMC-1 cells. In addition, we report for the first time that BT significantly inhibited the production and mRNA expression of proinflammatory cytokines including thymic stromal lymphopoietin, interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor-α in activated HMC-1 cells. BT also decreased the activation of mitogen-activated protein kinases, nuclear factor-κB, and caspapase-1. Taken together, these results indicate that BT has potential as a regulator of inflammatory reactions for the treatment of arthritis such as osteoarthritis and rheumatoid arthritis.

키워드

rheumatoid arthritis BaekJeol-Tang mast cells caspase-1 thymic stromal lymphopoietin ostheoarthritis