Acute oral toxicity of Dendropanax morbiferus H.Lév leaf extracts in ICR mice

• 영문명: Acute oral toxicity of Dendropanax morbiferus H.Lév leaf extracts in ICR mice
• 발행기관: 한국예방수의학회
• 저자명: Chang-Soo Cho Jiyong Park Jun-Ho Song Yeung Bea Jin Kwang Il Park Woo Hyun Kim Suk Kim Hu-Jang Lee
• 간행물 정보: 『Journal of Preventive Veterinary Medicine』Vol.47, No.1, 7~12쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.03.30

영문 초록

In this study, the acute toxicity of Dendropanax morbiferus H.Lév leaf hot-water extracts (DMWE) was examined in male and female ICR mice. Mice were orally administered the DMWE at dose levels of 0, 250, 500, 1,000 and 2,000 mg/kg body weight (BW) for single-dose toxicity test. There were no significant differences in change of BW between control and all DMWE treated-groups. In hematological and blood biochemical analysis, none of the parameters were affected by the DMWE. Similarly, there were no significant effects on markers for liver and kidney functions in all DMWE treated-groups. Since there were no adverse effects of the DMWE in single oral toxicity tests, even at the highest doses, it was concluded that the lethal dose 50 (LD50) of DMWE is estimated at > 2,000 mg/kg BW.

목차

서론

재료 및 방법

결과

고찰

감사의 글

REFERENCES

키워드

Dendropanax morbiferus Hot-water extracts Single oral dose toxicity test ICR mouse