Endothelial cell autophagy in the context of disease development

• 영문명: Endothelial cell autophagy in the context of disease development
• 발행기관: 대한해부학회
• 저자명: Basheer Abdullah Marzoog
• 간행물 정보: 『Anatomy and Cell Biology』Vol.56(1), 16~24쪽, 전체 9쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2023.03.31

영문 초록

Endothelial cells (EC) are the anatomical boundaries between the intravascular and extravascular space. Damage to ECs is catastrophic and induces endothelial cell dysfunction. The pathogenesis is multifactorial and involves dysregulation in the signaling pathways, membrane lipids ratio disturbance, cell-cell adhesion disturbance, unfolded protein response, lysosomal and mitochondrial stress, autophagy dysregulation, and oxidative stress. Autophagy is a lysosomal-dependent turnover of intracellular components. Autophagy was recognized early in the pathogenesis of endothelial dysfunction. Autophagy is a remarkable patho (physiological) process in the cell homeostasis regulation including EC. Regulation of autophagy rate is disease-dependent and impaired with aging. Up-regulation of autophagy induces endothelial cell regeneration/differentiation and improves the function of impaired ones. The paper scrutinizes the molecular mechanisms and triggers of EC dysregulation and current perspectives for future therapeutic strategies by autophagy targeting.

목차

Introduction

Potential Endothelial Cell Autophagy Triggers and Mechanism

Types of Endothelial Cells

Autophagy in Endothelial Cell Aging as a Marker

Current Approaches for Future Therapeutic Strategy

Discussion

Conclusion

ORCID

Author Contributions

Conflicts of Interest

References

키워드

Endothelial cells Autophagy Molecular medicine Regeneration