RANKL 유도 파골세포 분화를 억제하는 savinin의 효능

• 영문명: Effect of Savinin to Inhibit RANKL-induced Osteoclast Differentiation
• 발행기관: 대한약학회
• 저자명: 신한별 이용진 이민아 손영진
• 간행물 정보: 『약학회지』제67권 제1호(2023년), 8~14쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.02.28

영문 초록

Osteoporosis is a disease in which bone density is decreased and fractures occur easily due to external environment. The treatment of osteoporosis is important to prevent bone loss and to suppress the formation of osteoclasts involved in bone resorption. Osteoclasts, which are multinucleated cells, are greatly increased and overactivated in bone diseases including osteoporosis and rheumatoid arthritis. In this study, the effect of savinin on osteoclast differentiation by RANKL was investigated. Savinin significantly inhibited RANKL-induced osteoclast differentiation by inhibiting the transcriptional and translational expression of NFATc1, an essential component of RANKL-mediated osteoclast formation. In addition, mRNA expressions of OSCAR, DC-STAMP, and CTSK related to osteoclast differentiation and function were suppressed. Inhibition of osteoclast activity was verified through bone resorptive assay. Therefore, it is confirmed that savinin inhibits osteoclast differentiation, so it has the potential to be used as a therapeutic agent for the treatment of osteoporosis.

목차

서론(Introduction)

방법(Methods)

결과(Results)

고찰(Discussion)

결론(Conclusion)

감사의 말씀(Acknowledgment)

Conflict of Interest

References

키워드

Bone Osteoporosis Osteoclast RANKL NFATc1 Savinin