Immunomodulatory Role of Neuropeptide Y in Intestinal Inflammation

• 영문명: Immunomodulatory Role of Neuropeptide Y in Intestinal Inflammation
• 발행기관: 대한약학회
• 저자명: Yunna Lee Eunok Im
• 간행물 정보: 『약학회지』제67권 제1호(2023년), 1~7쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2023.02.28

영문 초록

Neuropeptide Y (NPY) is a 36-amino acid peptide found in the brain, autonomic nervous system, and different peripheral tissues, including the gastrointestinal (GI) tract. Dysfunction of the NPY or NPY system has been implicated in various tumor microenvironments and cardiovascular and GI disorders, such as inflammatory bowel disease (IBD). IBD, including Crohn’s disease (CD) and ulcerative colitis (UC), is a major health concern due to its increasing incidence globally. Emerging evidence has demonstrated that NPY also acts as a potent immunomodulator by linking the nervous and immune systems. NPY plays an important role in immunopathology during intestinal inflammation. This paper discusses the potential role of NPY as a valuable biomarker for IBD due to its consistent upregulation in both in vivo and clinical studies. Consequently, it confirms the pro-inflammatory effects of NPY, providing a rational basis for targeting NPY signaling as a therapeutic strategy.

목차

Introduction

Localization of NPY in the gut

Inflammatory bowel disease

Alteration of NPY expression during colitis

Role of NPY in intestinal inflammation

NPY as an immune modulator in IBD

Conclusion

Acknowledgment

Conflict of Interest

References

키워드

Neuropeptide Y Intestinal inflammation IBD Immune modulator