The impact of age on the morphology of the 12th thoracic vertebral endplates

• 영문명: The impact of age on the morphology of the 12th thoracic vertebral endplates
• 발행기관: 대한해부학회
• 저자명: Nefeli Garoufi Andreas Bertsatos Marie Louise Schjellerup Jørkov Chiara Villa
• 간행물 정보: 『Anatomy and Cell Biology』Vol.55(4), 441~451쪽, 전체 11쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2022.12.31

영문 초록

The current article explores the aging effects on the overall morphology of the endplates of the 12th thoracic vertebra (T12), while screening for sex differences. It further evaluates the suitability of T12 for estimating age-at-death in bioarcheaological contexts. We captured the morphology of the vertebral endplates, including the formation of osteophytes, in a novel continuous quantitative manner using digital photography. 168 Greek adults from the Athens Collection were used for modeling the aging effects and another 107 individuals from two Danish archaeological assemblages for evaluation. Regression analysis is based on generalized additive models for correlating age-at-death and morphological variation. Our proposed measurement method is highly reliable (R>0.98) and the main differences observed between sexes are size related. Aging has considerable effect on the endplate morphology of the T12 with the total area of the endplate, the area of the epiphyseal rim, and the shape irregularities of the endplate’s external boundary being mostly affected. Multivariate regression shows that aging effects account up to 46% of the observed variation, although with differential expression between sexes. Correct age prediction on archaeological remains reached 33% with a prominent tendency for overestimation. The morphology of the T12 endplates is influenced by age and it can provide some insight with respect to the age-at-death of unidentified individuals, especially when other skeletal age markers are unavailable. Our proposed method provides an ageestimation framework for bioarchaeological settings, especially for estimating broader age ranges, such as discriminating between young and old adults.

목차

Introduction

Materials and Methods

Results

Discussion

Conclusion

ORCID

Author Contributions

Conflicts of Interest

Acknowledgements

References

키워드

Aging effects 12th thoracic vertebra Vertebral endplate morphology Generalized additive models Age-at-death estimation