학술논문
Comparative histological study on the effect of tramadol abuse on the testis of juvenile and adult male albino mice
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- 영문명
- Comparative histological study on the effect of tramadol abuse on the testis of juvenile and adult male albino mice
- 발행기관
- 대한해부학회
- 저자명
- Amal T. Abou Elghait Tarek. M. Mostafa Fatma K. Gameaa Gamal K. Mohammed Fatma Y. Meligy
- 간행물 정보
- 『Anatomy and Cell Biology』Vol.55(3), 341~355쪽, 전체 15쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2022.09.30
국문 초록
영문 초록
As a synthetic analog of codeine, tramadol is often prescribed to treat mild to moderate pains. This study was designed to estimate and compare the histological effect of tramadol on testes of both juvenile and adult male albino mice. A total number of 40 healthy male albino mice were classified into two main groups as follows: group I (juvenile group, includes 20 mice aged three weeks) subdivided equally into group Ia (control group received isotonic saline) and group Ib (tramadol-treated group received 40 mg/kg/d tramadol orally for 30 days); group II (adult group, includes 20 mice aged two months) subdivided equally into group IIa (control group received isotonic saline) and group IIb (tramadol-treated group). Juvenile and adult tramadol-treated groups showed numerous testicular changes, including blood vessels congestion, widening of intercellular spaces, vacuolization in interstitial tissues, luminal germ cells exfoliation, and increased expression of caspase-3 that indicated cellular apoptosis. In the ultrastructural examination, spermatogenic cells degenerated with the frequent appearance of apoptotic cells. Sertoli cells showed vacuolations, large lipid droplets, and disrupted intercellular cell junctions. These observed testicular changes were markedly observed in the juvenile group. Testicular abnormalities and apoptotic changes can be caused by tramadol administration. These abnormalities are more common in juvenile mice.
목차
Introduction
Materials and Methods
Results
Discussion
ORCID
Author Contributions
Conflicts of Interest
References
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