한국인의 일반 · 전문의약품-한약제제 병용 처방 실태분석 및 잠재적 상호작용 고찰

• 영문명: Concurrent Use of Prescribed OTC · ETC Drugs and Herbal Medicines in South Korea: Exploring Potential Herb-drug Interactions
• 발행기관: 대한약학회
• 저자명: 박상준(Sang-Jun Park) 오인선(In-Sun Oh) 박민정(Minjung Park) 장보형(Bo-Hyoung Jang) 신주영(Ju-Young Shin)
• 간행물 정보: 『약학회지』제66권 제2호(2022년), 90~96쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2022.04.30

영문 초록

Herbal medicines have gained a reputation for being efficacious and safe over hundreds of years. Nowadays, people are easily exposed to drugs and herbal medications concurrently. Therefore, it is essential for regulatory authorities and physicians to closely monitor potential herb-drug interactions. The aim of this study was to determine (1) the prevalence of the concurrent use of drugs and herbal medications, (2) demographic and clinical characteristics of concurrent users, (3) risk factors associated with concurrent use, (4) prescription patterns, and (5) potential herb-drug interactions by using a nationwide insurance claims database. We included patients with herbal medicine records in 2010- 2015 from the National Health Insurance Service-National Sample Cohort 2.0. The herbal medicine users were divided into two groups: concurrent users who were prescribed both herbal and drug medications simultaneously and non-concurrent users. The proportion of concurrent use increased steadily from 2.5% in 2010 to 5.2% in 2015, and the growth rate in the elderly population aged 60-79 years was the highest, from 0.7% in 2010 to 2.8% in 2015. Concurrent users in 2015 were prone to be female; old; and have chronic diseases including hypertension (adjusted odds ratio [aOR], 4.89; 95% CI, 4.54-5.27), hyperlipidemia (aOR, 2.01; 1.89-2.14), and diabetes (aOR, 1.81; 1.67-1.98). The most common concurrently used combinations were Gunghatang-aspirin, Ojeoksan-aspirin, and Ojeoksan-atorvastatin. In this study, we investigated the herb-drug combinations that are used concurrently and related characteristics and elucidated the factors related to the concurrent use and the most common concurrently used herb-drug combinations.

목차

서론(Introduction)

방법(Methods)

결과(Results)

고찰(Discussion)

결론(Conclusion)

감사의 말씀(Acknowledgment)

Conflict of Interest

References

키워드

Drug Herbal medicine Concurrent use Herb-drug interaction