하이퍼로사이드가 기도 상피세포에서의 뮤신 유전자 발현 및 생성과 EGFR-p44/42-Sp1 신호전달 경로에 미치는 영향

• 영문명: Effect of Hyperoside on the Gene Expression and Production of Mucin and EGFR-p44/42-Sp1signaling Pathway in Airway Epithelial Cells
• 발행기관: 대한약학회
• 저자명: 이현재(Hyun Jae Lee)
• 간행물 정보: 『약학회지』제66권 제2호(2022년), 104~109쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2022.04.30

영문 초록

Hyperoside is an anti-inflammatory natural product derived from a medicinal plant Houttuynia cordata, empirically used as remedies for controlling the pulmonary inflammatory diseases in folk medicine. In this study, hyperoside was investigated for its potential effect on the gene expression and production of airway mucin 5AC (MUC5AC). Human airway epithelial NCI-H292 cells were pretreated with hyperoside for 30 min and stimulated with epidermal growth factor (EGF) for the following 24 h. For the elucidation of the action mechanism of hyperoside, EGFinduced epidermal growth factor receptor (EGFR) signaling pathway was investigated. Hyperoside inhibited EGF-induced gene expression and production of MUC5AC mucin through regulating the phosphorylation of EGFR, phosphorylation of extracellular signal-regulated kinase (ERK) 1/2 (p44/42), and the nuclear expression of specificity protein-1 (Sp1). These results suggest hyperoside could regulate the gene expression and production of MUC5AC by modulating the EGFR signaling pathway in human airway epithelial cells.

목차

서론(Introduction)

방법(Methods)

결과 및 고찰(Results and Discussion)

결론(Conclusion)

Conflict of Interest

References

키워드

Airway MUC5AC mucin Hyperoside