고지방식이로 유도된 비만 동물 모델에서 평위산, 후박, 창출의 항비만 효능 비교 연구

• 영문명: Comparative Study on Anti-obesity Effects of Pyungwi-san, Magnolia officinalis, and Atractylodes chinensis in High-fat Diet-induced Obese Mouse Model
• 발행기관: 대한미병의학회
• 저자명: 서민규(Min-gyu Seo) 박예진(Yea-Jin Park) 강윤미(Yun-Mi Kang) 김희영(Hee-Young Kim) 한인식(Insik Han) 안효진(Hyo-Jin An)
• 간행물 정보: 『대한미병의학회지』제3권 제1호, 1~12쪽, 전체 12쪽
• 주제분류: 의약학 > 한의학
• 파일형태: PDF
• 발행일자: 2022.03.30

영문 초록

Objectives Obesity is considered a global epidemic that greatly affects general population health, and there has been a growing interest in the development of anti-obesity drugs worldwide. There are many hepatic and gastrointestinal diseases for which obesity is the direct cause or is a serious risk factor. Pyungwi-san (PWS) is a traditional oriental herbal prescription used to treat gastrointestinal disorders. Atractylodes chinensis (DC.) Koidzumi (AC) and Magnolia officinalis Rehder & E.H. Wilson (MO) are main components of PWS. In this present study, anti-obesity effects of PWS, MO, and AC were investigated in high-fat diet (HFD)-induced obese mouse model. Methods Eight-week-old male C57BL/6N were fed 45% HFD for 8 weeks. For comparison of PWS, MO, and AC for obesity, the body weight, food intake, and white adipose tissue (WAT) weights were checked. In addition, hematoxylin and eosin staining for histological examination were performed to observe lipid droplets in epididymal WAT and liver tissue. Results Among them, AC had powerful effects on reduction of body weight, epididymal and visceral WAT weight, and regulation of the levels of serum total cholesterol and triglyceride. In addition, PWS, MO, and AC treatment ameliorated the HFD-induced histological changes in the epididymal WAT and liver tissue. Conclusions These findings demonstrate that AC has anti-obesity effects and would be evaluated as a potential treatment for obesity.

목차

Introduction

Materials and Methods

Results

Discussion

Conclusion

Acknowledgement

Funding

Conflict of Interest

References

키워드

Pyungwi-san Magnolia officinalis Atractylodes chinensis Diet High-fat Obesity