환경성질환과 환경유해인자의 연관성을 규명하기 위한 독성 연구 고찰

• 영문명: A Systematic Review of Toxicological Studies to Identify the Association between Environmental Diseases and Environmental Factors
• 발행기관: 한국환경보건학회
• 저자명: 가유진(Yujin Ka) 지경희(Kyunghee Ji)
• 간행물 정보: 『한국환경보건학회지』제47권 제6호, 505~512쪽, 전체 8쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2021.12.31

영문 초록

Background: The occurrence of environmental disease is known to be associated with chronic exposure to toxic chemicals, including waterborne contaminants, air/indoor pollutants, asbestos, ingredients in humidifier disinfectants, etc. Objectives: In this study, we reviewed toxicological studies related to environmental disease as defined by the Environmental Health Act in Korea and toxic chemicals. We also suggested a direction for future toxicological research necessary for the prevention and management of environmental disease. Methods: Trends in previous studies related to environmental disease were investigated through PubMed and Web of Science. A detailed review was provided on toxicological studies related to the humidifier disinfectants. We identified adverse outcome pathways (AOPs) that can be linked to the induction of environmental diseases, and proposed a chemical screening system that uses AOP, chemical toxicity big data, and deep learning models to select chemicals that induce environmental disease. Results: Research on chemical toxicity is increasing every year, but there is a limitation to revealing a clear causal relationship between exposure to chemicals and the occurrence of environmental disease. It is necessary to develop various exposure- and effect-biomarkers related to disease occurrence and to conduct toxicokinetic studies. A novel chemical screening system that uses AOP and chemical toxicity big data could be useful for selecting chemicals that cause environmental diseases. Conclusions: From a toxicological point of view, developing AOP related to environmental diseases and a deep learning-based chemical screening system will contribute to the prevention of environmental diseases in advance.

목차

I. 서 론

II. 환경성질환에 관한 연구 추세

III. 가습기살균제로 인한 폐질환과 화학물질의 연관성 규명을 위한 독성학적 연구

IV. 환경성질환 예방관리를 위한 독성학적 연구의 방향

V. 결 론

Conflict of Interest

References

키워드

Adverse outcome pathway big data chemical environmental disease toxicity