Glutaminase 저해 항암제 개발의 최근 발전 사항들

• 영문명: Recent Advances in Development of Glutaminase Inhibitors as Anticancer Agents
• 발행기관: 대한약학회
• 저자명: 김규비(Gyubi Kim) 주한솔(Hansol Joo) 정종화(Jong-Wha Jung)
• 간행물 정보: 『약학회지』제65권 제5호(2021년), 344~348쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.10.30

영문 초록

Glutaminolysis is closely related to uncontrolled tumor growth and metastasis in various glutamine-dependent cancers. As such, rewiring cancer metabolism using a glutaminolysis intervention has attracted much attention with recent progress in developing glutaminase inhibitors as anticancer agents. This review paper described the current understanding of glutaminases and their roles in cancers and small-molecule glutaminase inhibitors. In particular, recent developments of natural and synthetic glutaminase inhibitors were covered, focusing on their binding sites and isoform selectivity and briefly, on their structure-activity relationship. Some of the glutaminase inhibitors are in clinical trials, and if successful, it would lead to novel pharmacological intervention to effectively treat cancers.

목차

서론(Introduction)

Glutaminase Isoform과암에서의 역할(Glutaminase Isoforms and Their Role in Cancer)

저분자화합물 Glutaminase 저해제(Small Molecule Glutaminase Inhibitors)

결론(Conclusion)

감사의말씀(Acknowledgment)

Conflict of Interest

References

키워드

Cancer Glutaminolysis Glutaminase Small Molecule Inhibitor Anticancer Agent