1-아릴옥시메틸-2,4,5-트리플루오로벤젠 유도체의 합성 및 CCL2 발현의 억제 활성

• 영문명: Synthesis of 1-Aryloxymethyl-2,4,5-trifluorobenzene Analogs and Their Inhibitory Activity of CCL2 Expression
• 발행기관: 대한약학회
• 저자명: 김민정(Min Jung Kim) 조아영(Ahyoung Jo) 김관회(Koanhoi Kim) 곽재환(Jae-Hwan Kwak)
• 간행물 정보: 『약학회지』제65권 제5호(2021년), 370~374쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.10.30

영문 초록

CCL2 overexpression is associated with macrophage recruitment during immune response and poor patient prognosis in various cancers, such as prostate, breast, pancreatic, and liver cancer. For developing CCL2 inhibitors, 1-aryloxymethyl-2,4,5-trifluorobenzene analogs were designed and synthesized by concise synthetic route including SN2 reaction, reduction, and oxime formation reaction. Furthermore, it was confirmed that they inhibited CCL2 production induced by 27-hydroxycholesterol through reverse transcription PCR in the human acute monocytic leukemia cell line (THP-1). Among them, N-((2-(2,4,5-trifluorobenzyloxy)naphthalene-1-yl)methyl)hydroxylamine (4) exhibited the highest CCL2 transcription inhibition activity.

목차

서론(Introduction)

방법(Methods)

결과 및 고찰(Results and Discussion)

결론(Conclusion)

감사의 말씀(Acknowledgment)

Conflict of Interest

References

키워드

CCL2 expression (2,4,5-Trifluorobenzyloxy)benzene (2,4,5-Trifluorobenzyloxy)naphthalene