Thioacetamide로 유발된 간손상 동물모델에 인진호 추출물의 간보호 효과

• 영문명: Effect of Artemisia Capillaris Herba Water Extract on Thioacetamide-Induced Liver Injury Animal Model
• 발행기관: 대한약학회
• 저자명: 김민주(Min Ju Kim) 이진아(Jin A Lee) 이지혜(Ji Hye Lee) 신미래(Mi-Rae Shin) 노성수(Seong-Soo Roh)
• 간행물 정보: 『약학회지』제65권 제3호(2021년), 201~208쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2021.06.30

영문 초록

This study investigated the hepatoprotective effect of Artemisia Capillaris Herba water extract (AC) in a thioacetamide (TAA) induced acute liver damage model using Sprague-Dawley (SD) rats. The in vitro antioxidant activity of AC was measured by quantitating total polyphenol content, total flavonoid content, and DPPH and ABTS free radical scavenging. Our animal experiment was conducted as follows: AC (100 and 200 mg/kg body weight, PO) and silymarin (Sily 100; 100 mg/kg body weight, PO) were administered for 3 days, concurrent with induction of liver injury (TAA, 200 mg/kg body weight, IP). Serum and liver tissue were collected after 3 days of drug administration. AC treatment significantly reduced serum glutamic oxaloacetic transaminase (GOT), glutamate pyruvate transaminase (GPT), myeloperoxidase (MPO), and ammonia levels. It also effectively decreased protein level expression of NF-ĸBp65, p-IĸBα, COX-2, iNOS, TNF-α, IL-6, and IL-1β in liver tissue, while increasing ZO-1, occludin, claudin-1, claudin-3, and claudin- 4 expression. These results suggest that AC treatment can attenuate inhibition of the NF-ĸB pathway, and enhancement of the tight junction (TJ) pathway in TAA-induced liver injury. Therefore, AC displays potential for use as a natural therapeutic drug.

목차

서 론(Introduction)

방 법(Methods)

결 과(Results)

고 찰(Discussion)

결 론(Conclusion)

키워드

Artemisia Capillaris Herba thioacetamide liver injury