Changes in Muscle Biomarkers Following Swimming Exercise in Streptozotocin-induced Rats

• 발행기관: 대한운동학회
• 저자명: Youngsik Kim Storm Reid Eunkee Park Yehchan Ahn Byeonghwan Jeon
• 간행물 정보: 『아시아 운동학 학술지』제19권 제3호, 1~14쪽, 전체 14쪽
• 주제분류: 예술체육 > 체육
• 파일형태: PDF
• 발행일자: 2017.07.30

영문 초록

Changes In Muscle Biomarkers Following Swimming Exercise in Streptozotoxin-induced Rats. The Journal of Kinesiology, 2017, 19(3): 1-13 . [PURPOSE] The purpose of this study was to assess the effect of swimming exercise in diabetic atrophy by monitoring changes in biomarkers associated with musculoskeletal growth and abnormalities. [METHODS] Ninety-two male Sprague-Dawley rats were randomly divided into four groups: control plus exercise group (CO+Ex), control and no exercise group (CO+No Ex), diabetes plus exercise group (DM+Ex) and diabetes and no exercise group (DM+No Ex). Swimming exercise was implemented for 60 min/day, 5 day/week for a total of eight weeks. Muscle strength and atrophy biomarkers as well as muscle morphology were compared at the first, second, fourth and eighth week of experimentation. [RESULTS] ACE levels were significantly higher in the DM groups (p<.05), however swimming exercise did not significantly affect ACE levels. Irisin levels were significantly higher in the DM and DM+Ex groups compared to the CON, in week one (p<.05), and greater in the DM+Ex group at week two compared to CON+Ex (p<.05), but swimming did not significantly affect irisin levels over the eight-week period in DM rats. In terms of muscle damage, Myl3 expression was unchanged in the CON groups, but significantly higher in the DM+Ex group compared to the CON+Ex group (p<.05). AST was found to be in higher levels in the DM+No Ex group, compared to CON and CON+Ex (p<.05); and DM+Ex group, compared to the CON+Ex group at weeks one, four and eight (p<.05). Tibialis anterior muscle fibers were thicker in the DM+Ex group compared to DM+No Ex, but only at week four (p<.05). Otherwise, no other notable differences were recorded in muscle morphology. [CONCLUSIONS] These results suggest that swimming exercise alone may not be sufficient to induce muscle strength and/or protective effects against muscle atrophy associated with diabetes mellitus. However, this mode of exercise may be considered safe by not compounding the deteriorative effects of this disease.

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키워드

근위축 AST ACE irisin myl3 atrophy AST ACE irisin myl3