Anti-inflammatory effect of Arctium minus on LPS-stimulated RAW 264.7 cells

• 영문명: Anti-inflammatory effect of Arctium minus on LPS-stimulated RAW 264.7 cells
• 발행기관: 한국자원식물학회
• 저자명: Yang, Hye-Ji Jang, Min-Hye Kang, Yoon Joong
• 간행물 정보: 『한국자원식물학회 학술심포지엄』2019년도 춘계학술대회, 115~115쪽, 전체 1쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2019.04.30

영문 초록

Thalictrum rochebrunianum var. grandisepalum (TRG) is a Korean endemic plant, and it is widely used for edible, medicinal, landscape materials. In this study, we examined the protein and mRNA expression levels of MITF, tyrosinase, TRP-1 and TRP-2 by TRG extract (TRGE) in IBMX-treated melanocytes to evaluate the possibility of using TRG as a whitening material. IBMX were reported as melanin synthesis enhancers. It could increase intracellular melanin synthesis by activation of the microphthalmia-associated transcription factor (MITF) signaling pathway. TRGE did not show cytotoxicity at concentrations below $100{\mu}g/ml$ in B16F10 cells. TREG dose-dependently inhibited protein and mRNA levels of MITF, tyrosinase, TRP-1 and TRP-2. Therefore, we suggest that TRGE is an important natural resource for cosmetic raw materials for whitening function.