굼벵이 추출물의 DSS유도 궤양성 대장염 조절효능 탐색

• 영문명: Protaetia brevitarsis extract ameliorates the severity of DSS-Induced Ulcerative Colitis in vivo
• 발행기관: 한국자원식물학회
• 저자명: Park, Bog-Im Jeon, Yong-Deok Sim, Hyeon-Jae Lee, Hoon-Yeon Kim, Seong-Oh kim, Dong-Keun Jo, Mi-Na Cho, Yong-Jin Kim, Chong-Tai Kim, Tae-Eun Jin, Jong-Sik
• 간행물 정보: 『한국자원식물학회 학술심포지엄』2019년도 춘계학술대회, 122~122쪽, 전체 1쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2019.04.30

영문 초록

Xanthone is a kind of polyphenolic compounds that contain a distinctive chemical structure with a tricyclic aromatic ring found in a few higher plant families e.g. gentian root. This compound had a variety of biological activity, for instance antioxidant, antibacterial, anti-inflammatory, and anticancer effects. However, the effect of xanthone on mast cell-mediated allergic inflammation and its associated mechanism have not been elucidated. Therefore, the aim of this study was to elucidate the anti-allergic inflammatory effects and the underlying molecular mechanism of xanthone in PMACI-stimulated human mast cells-1 (HMC-1). In this result, xanthone treatment decreased the production of histamine, pro-inflammatory cytokines such as tumor necrosis factor-a (TNF-${\alpha}$), IL-6, and IL-8 and expressions of TSLP in PMACI-stimulated HMC-cells. In addition, xanthone significantly suppressed the phosphorylation of MAPKs and the activation of NF-${\kappa}B$ signal pathway in activated mast cells. Furthermore, xanthone inhibited the activation of caspase-1, an IL-$1{\beta}$ converting enzyme, in PMACI-stimulated HMC-1 cells. These findings provide evidence that xanthone could be a potential therapeutic agent for allergy-related inflammatory disorders.

키워드

Xanthone human mast cells pro-inflammatory mediators