사염화탄소를 투여한 흰쥐의 지질농도에 미치는 식물추출물의 보호효과

• 영문명: Protective Effects of Some Plant Extracts on Lipids Contents of Rats Treated with Carbon Tetrachloride
• 발행기관: 한국자원식물학회
• 저자명: 최용순(Yong-Soon Choi) 김성완(Sung-Wan Kim)
• 간행물 정보: 『한국자원식물학회지』제13권 제3호, 171~178쪽, 전체 8쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2000.10.30

국문 초록

본 실험은 간장기능보호를 위한 식품소재를 검토하기 위하여 수행되었다. 인진쑥, 콩나물, 솔잎추출물은 in vitro 간장 fatty acid synthase 활성을 억제하였다. 한편, 솔잎, 콩나물추출물은 사염화탄소를 처리한 횐쥐의 혈청 GPT및 GOT효소활성의 상승을 억제하였다. 인진쑥, 콩나물추출물은 사염화탄소처리에 의한 흰쥐의 간장 microsome의 과산화지질함량의 상승을 억제하였다. 나아가 콩나물추출물은 사염화탄소에 의해 증가한 흰쥐의 간장콜레스테롤 및 중성지질함량을 현저하게 감소시켰다. 이러한 결과는 인진쑥, 솔잎, 콩나물추출물의 사염화탄소에 의한 간장손상의 보호기능을 보여 준다.

영문 초록

This study was performed to investigate the possible effects of some plants protecting intact rat liver damaged by CCl4. The extract of mugwort (Artemsiae capillaris), soybean sprout and pine leaf (Pinus strobus) inhibited markedly the in vitro activities of rat liver fatty acid synthase, whereas those of shiitake (Lentinus ododes), Houttuynia cortata, Acanthopanacis cortex and buckwheat leaves had less effects. Treatment with the water extract of pine leaf and soybean sprout caused a marked decrease in the CCl4-induced toxicity in rat liver, judged from their effects on the levels of glutamic oxaloacetic transaminase (GOT) and glutamate pyruvic transaminase(GPT) in the serum. The extract of mugwort and soybean sprout reduced markedly the content of liver microsomal peroxides induced by CCl4 treatment and serum TBA values, respectively. The extract of soybean sprout decreased efficiently the content of liver triglyceride elevated by CCl4 treatment. Nevertheless, the extracts did not exert the supression of hepaticmegaly induced by CCl4. The results suggest that soybean sprout and pine leaf may be potential sources improved the biochemical parameters like as peroxidation value or serum GOT and GPT, although these extracts had minimal effects in the increase of liver size induced by carbon tetrachloride.　

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키워드

Plant extracts CCl4-toxicity soybean sprout fatty acid synthase rats