Isolation of Dineolignans, Saucernetin-7 and -8, with Nitric Oxide Inhibitory Activity and NMR assignment from Saururus chinensis

• 영문명: Isolation of Dineolignans, Saucernetin-7 and -8, with Nitric Oxide Inhibitory Activity and NMR assignment from Saururus chinensis
• 발행기관: 한국자원식물학회
• 저자명: Lee, Kyung-Tae Jung, Hyun-Ju Park, Hee-Juhn
• 간행물 정보: 『한국자원식물학회지』제19권 제6호, 655~659쪽, 전체 5쪽
• 주제분류: 농수해양 > 기타농수해양
• 파일형태: PDF
• 발행일자: 2006.12.30

영문 초록

Two dineolignans (1,2) with nitric oxide inhibitory activities were isolated from Saururus chinensis (Saururaceae) using silica gel column chromatography. Although the structures, saucernetin-7 (1) and -8 (2), have been already reported, NMR assignment of the two compounds was completed aided by 2D-NMR spectroscopy including 1H−1H COSY, 1H−13C COSY, HMBC and NOESY NMR spectra. Compounds 1 and 2 exhibited significant nitride oxide inhibitory activity in LPS-induced RAW 264.7 cells with IC50 values of 11.3μMand7.1μM, respectively.

키워드

Saururus chinensis Saururaceae Dineolignan Lignan Saucernetin NMR assignment