실험동물 랫드를 이용한 미세먼지 기도노출에 따른 호흡기계 독성에 대한 마늘의 예방효과 탐색

• 영문명: Preventive Effect of Garlic Administration on Respiratory Toxicity Induced through Intratracheal Instillation of Fine Dust (PM₁₀) in Rats
• 발행기관: 한국환경보건학회
• 저자명: 이윤범(YoonBum Lee) 김근우(GeunWoo Kim) 송영민(YoungMin Song) 한영훈(YoungHoon Han) 하창수(ChangSu Ha) 이지선(JiSun Lee) 김민희(MinHee Kim) 손혜영(HyeYoung Son) 이기용(GiYong Lee) 허 용(Yong Heo) 김창열(ChangYul Kim)
• 간행물 정보: 『한국환경보건학회지』제46권 제6호, 667~675쪽, 전체 9쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2020.12.31

영문 초록

Objectives: Exposure to fine dust (PM10) could contribute to the occurrence of cardiovascular disease or respiratory abnormalities. Since garlic is known to possess an anti-oxidative stress effect, the present study was performed to evaluate the effect of garlic intake on fine dust-mediated pulmonary toxicity. Methods: Rats were intratracheally instilled with fine dust at 15 mg/kg body weight (BW)/day for five days following five-day intragastric intubation of garlic at 0.7 or 1.4 g/kgBW/day, or 13.1 mg/kgBW/day S-allyl-cysteine (SAC) as a reference component in garlic. Blood and bronchoalveolar lavage fluid (BALF) were collected. Results: Deposit of fine dust was visually and histopathologically observed in the lungs. Body weight gain during the instillation period was significantly lowered in all the groups instilled with fine dust. Neutrophil numbers in blood were significantly elevated in the fine dust alone group, but this alteration was diminished in the groups administered with garlic. Levels of serum glutathione were lower in the rats instilled with fine dust alone, and this decrease in the glutathione level seems dose-dependently compensated among the groups administered with garlic. Similar findings were observed in the BALF with statistical significance. Typical pulmonary histopathological observation related with inflammation was demonstrated in the lungs of the rats exposed to fine dust alone, whereas such histopathologic findings were not improved in the groups administered with garlic. Conclusion: The present study suggests that garlic intake could alleviate fine dust-mediated pulmonary or systemic toxicities. Further investigation is necessary to delineate the mechanism of garlic-mediated effects on pulmonary function.

목차

I. 서 론

II. 연구 방법

III. 결 과

IV. 고 찰

V. 결 론

감사의 글

키워드

Fine dust instillation garlic intake glutathione oxidative stress pulmonary inflammation