곰팡이에 감작된 소아 천식 환자 가정내 환경유해물질 농도와 폐기능의 상관관계

• 영문명: The Relationship between Indoor Air Pollutants and Pulmonary Function in Asthmatic Children with Mold Sensitization
• 발행기관: 한국환경보건학회
• 저자명: 윤원석(Wonsuck Yoon) 임재훈(Jaehoon Lim) 박상현(Sang Hyun Park) 이민규(Mingyu Lee) 유 영(Young Yoo)
• 간행물 정보: 『한국환경보건학회지』제46권 제6호, 685~693쪽, 전체 9쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2020.12.31

영문 초록

Objectives: Recent data indicate that sensitization to mold contributes to the severity and persistence of asthma. The aim of this study was to investigate relationships between indoor mold concentrations and pulmonary function parameters in asthmatic children with mold sensitization. Methods: Asthmatic subjects who had a positive result in skin-prick testing to more than one mold allergen, such as Alternaria, Aspergillus, or Penicillium, were enrolled. Their pulmonary function and methacholine challenge test results were collected. Measurements of blood eosinophil, serum IgE, and fractional exhaled nitric oxide (FeNO) were taken. Indoor levels of VOC, CO2, PM10 and PM2.5 in each subject’s house were measured. We counted mold and bacteria colonies from the subjects’ house air samples. Results: The mean levels of FEV1, FVC, FEV1/FVC, and FEF25-75 were 82.8±19.7, 87.3±17.9, 85.8±8.3, and 82.3±28.9%, respectively. The mean FeNO level was 19.8±11.2 ppb and the geometric mean (range of one SD) of methacholine PC20 was 3.99 mg/mL (0.67-23.74 mg/mL). The average indoor air pollutant levels were below the recommended levels set by the Ministry of Environment for multiplex buildings. Indoor mold levels showed a significant inverse correlation with methacholine PC20, but not with the baseline pulmonary function parameters. Conclusion: Indoor mold concentrations are a risk factor for increased bronchial hyperresponsiveness among asthmatic children with mold sensitization. Targeted environmental intervention should be considered for selected asthmatic children with mold sensitization for avoiding severe airway hyperresponsiveness.

목차

I. 서 론

II. 연구 방법

III. 결 과

IV. 고 찰

V. 결 론

감사의 글

References

키워드

Asthma mold environment airway hyperr esponsiveness pulmonary function parameters