Effect of Eleutheroside E from Eleutherococcus senticosus on the Contractility of Rabbit Penile Corpus Cavernosum Smooth Muscle

• 발행기관: 대한약학회
• 저자명: Min-Ji Kim Yun-Sik Choi Young-Ah Jang Hye Kyung Kim
• 간행물 정보: 『약학회지』제64권 제4호(2020년), 307~311쪽, 전체 5쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2020.08.30

영문 초록

The relaxant effect of extract, fractions and major component, eleutheroside E, from Eleutherococcus senticosus was evaluated on penile corpus cavernosum smooth muscle (PCCSM) in a rabbit. The PCCSM contracted with 10 μM phenylephrine (Phe) was treated with extract and three fractions partitioned with n-hexane, ethyl acetate and n-butanol at a range of 1-4 mg/ml. Eleutheroside E was tested at final concentrations of 0.1, 1, 10 and 100 μM. The interaction of eleutheroside E with phosphodiesterase type 5 (PDE5) inhibitor, udenafil, was also evaluated on PCCSM tension. The relaxations induced by ethanol extract and three fractions on PCCSM were effective in a dose-dependent manner and the relaxation of ethyl acetate fraction was the highest. Eleutheroside E dose-dependently induced the PCCSM relaxation and showed an additive effect with udenafil on PCCSM. The extract, ethyl acetate fraction and eleutheroside E from E. senticosus relaxed the Phe-precontracted PCCSM and eleutheroside E enhanced the udenafil-induced relaxation. It can be an alternative or supplement for patients with erectile dysfunction who want herbal medicines to improve penile erection or who do not completely respond to udenafil.

목차

Introduction

Experimental Methods

Results

Discussion

Conclusion

Acknowledgment

Conflict of Interest

References

키워드

Eleutherococcus senticosus eleutheroside E penile corpus cavernosum smooth muscle phosphodiesterase type 5 inhibitor