용해도가 개선된 티카그렐러 고체분산체 함유 정제의 개발

• 영문명: Development of a Novel Ticagrelor Solid Dispersion-loaded Tablet with Enhanced Solubility
• 발행기관: 대한약학회
• 저자명: 최형주(Hyung Ju Choi) 김경수(Kyeong Soo Kim)
• 간행물 정보: 『약학회지』제64권 제1호(2020년), 21~27쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2020.02.29

영문 초록

The objective of this study was to develop a novel ticagrelor (TC) solid dispersion-loaded tablet with enhanced solubility. Numerous polymers and surfactant were screened, and then Kollidon VA64 and Poloxamer 407 were selected as a soluble polymer and a surfactant for preparing TC solid dispersions. Various solid dispersions were prepared by spraydrying process, and the physicochemical properties, solubility and dissolution profile were investigated. The TC solid dispersion consisted of TC, Kollidon VA64, Poloxamer 407 and colloidal silica at a weight ratio of 1/1/4/1, provided an amorphous drug and spherical particle shape. Moreover, it exhibited excellent solubility and dissolution rate compared to the TC. The TC solid dispersion-loaded tablet were prepared and their dissolution were evaluated compared to commercial TC tablet. The required time for complete release of the TC solid dispersion and the TC solid dispersion-loaded tablet were within 60 min and 8 hrs in various dissolution media. However commercial TC tablets showed low dissolution rate less than 10% in pH 1.2, 4.0 and 6.8 buffer up to 8 hrs. Thus, we successfully prepared the TC solid dispersion-loaded tablet for enhancing solubility of TC and this novel TC solid dispersion-loaded tablet could be a potential alternative for commercial TC tablet.

목차

서 론(Introduction)

실험 방법(Experimental Methods)

결과 및 고찰(Results and Discussion)

결 론(Conclusion)

감사의 말씀(Acknowledgments)

Conflict of Interest

References

키워드

ticagrelor solid dispersion tablet solubility dissolution