고온용융 압출과 3차원 프린팅 접목을 통한 테오필린 함유 서방정 개발

• 영문명: Fabrication of Theophylline-loaded Sustained Release Tablet via Coupling of Hot Melt Extrusion and 3D Printing
• 발행기관: 대한약학회
• 저자명: 송언수(Eon Soo Song) 서영준(Youngjun Seo) 김동욱(Dong Wuk Kim)
• 간행물 정보: 『약학회지』제63권 제5호(2019년), 297~302쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2019.10.30

영문 초록

The objective of this study was to develop a new approach for fabrication of 3D printed tablet containing active pharmaceutical ingredients (APIs), exploiting the hot-melt extrusion (HME) coupled with 3D printing technology. Theophylline was used as a model drug, and hydroxypropyl cellulose (HPC), hydroxypropyl methylcellulose (HPMC) and stearic acid (SA) were used as a carrier or plasticizer for the preparation of drug-loaded filaments. Four different compositions were hot-melt extruded, and three of them available for 3D printing showed a zero-order sustained release over 9 hours. Overall, 3DP technology coupled with HME could be a novel method to produce controlled release tablets providing the advantage of simplicity and versatility than the conventional method.

목차

서 론(Introduction)

실험방법(Experimental Methods)

결과 및 고찰(Results and Discussion)

결 론(Conclusion)

키워드

hydroxypropyl cellulose hydroxypropyl methylcellulose theophylline hot-melt extrusion fused deposition modeling 3D printing