Vitamin C restores ovarian follicular reservation in a mouse model of aging

• 발행기관: 대한해부학회
• 저자명: Mohammad-Amin Abdollahifar Nahid Azad Ensieh Sajadi Zahra Shams Mofarahe Fatemeh Zare Ali Moradi Fatereh Rezaee Mohammad Gholamin Shabnam Abdi
• 간행물 정보: 『Anatomy and Cell Biology』Vol.52(2), 196~203쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2019.06.30

영문 초록

Ovarian aging is related to the reduction of oocyte quality and ovarian follicles reservation leading to infertility. Vitamin C is a natural antioxidant which may counteract with adverse effects of aging in the ovary. The aim of this study was to evaluate the possible effect of vitamin C on NMRI mice ovarian aging according to the stereological study. In this experimental study, 36 adult female mice (25–30 g) were divided into two groups: control and vitamin C. Vitamin C (150 mg/kg/day) were administered by oral gavage for 33 weeks. Six animals of each group were sacrificed on week 8, 12, and 33, and right ovary samples were extracted for stereology analysis. Our data showed that the total volume of ovary, cortex, medulla and corpus luteum were significantly increased in vitamin C group in comparison to the control groups (P≤0.05). In addition, the total number of primordial, primary, secondary, and antral follicles as well as granulosa cells were improved in vitamin C group in compared to the control groups (P≤0.05). No significant difference was observed in total volume of oocytes in antral follicles between control and vitamin C groups. Our data showed that vitamin C could notably compensate undesirable effects of ovarian aging in a mouse model.

목차

Introduction

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키워드

Aging Follicular reserve Ovary Vitamin C