Safety of Bevacizumab on Extraocular Muscle in a Rabbit Model

• 발행기관: 대한안과학회
• 저자명: Jae Ho Jung Jung Hoon Lee Ji Eun Lee Hee Young Choi
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.26 No.4, 290~296쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.08.30

영문 초록

Purpose: The purpose of this study was to investigate the myotoxicity of bevacizumab on extraocular muscles in a rabbit model. Methods: Thirty New Zealand white rabbits were used for this study. The animals were evenly divided into two groups. In the first group, 15 rabbits were treated with intramuscular injections of bevacizumab (1.25 mg/0.05 mL) in the right superior rectus muscle and normal saline solution (0.05 mL) in the left superior rectus muscle. In the second group, 15 rabbits were treated with subconjunctival injections of bevacizumab (2.5 mg/0.1 mL) in the right superior subconjunctival area and normal saline solution (0.1 mL) in the left superior subconjunctival area. Five rabbits in each group were sacrificed at one day, two weeks and four weeks after the injections. Extraocular muscle samples were prepared for light microscopic (LM) and electron microscopic (EM) examination. Degrees of acute inflammation were evaluated via CD-11b immunohistochemistry, and global muscle change was investigated using hematoxylin and eosin stains. Intensity of fibrosis was evaluated using Masson trichrome stains, and ultrastructural changes were observed on EM. Results: We observed no significant inflammatory cell infiltration, muscle necrosis or fibrotic change in treated and control eyes. EM findings revealed no significant damage to muscle or vascular tissue after bevacizumab injection. Conclusions: We found no signs of extraocular muscle toxicity after LM and EM intramuscular and subconjunctival bevacizumab injections in a rabbit model.

목차

Materials and Methods

Results

Discussion

Conflict of Interest

Acknowledgements

References

키워드

Bevacizumab Extraocular muscle Myotoxicity