아테놀롤의 비강 및 장관 투과에 대한 C-말단 변형 밀착결합 조절제와 프룩토스 폴리머의 영향

• 영문명: Effect of C-terminal Amidated Tight Junction Modulator and Fructose Polymer on the Nasal and Intestinal Permeation of Atenolol
• 발행기관: 대한약학회
• 저자명: 송건형(Keon-Hyoung Song)
• 간행물 정보: 『약학회지』제63권 제1호(2019년), 37~42쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2019.01.30

영문 초록

Zonula occludens toxin has been shown to reversibly open tight junctions in endothelial and epithelial cells. The purpose of this study was to evaluate the permeation activity of C-terminal amidated fragment of Zonula occludens toxin and co-administration with a fructose polymer on enhancing the nasal and duodenal administration of atenolol. The C-terminal amidated peptide (Phe-Cys-Ile-Gly-Arg-Leu-NH2) resulted in statistically significant improvement in permeation of atenolol compared to the control in both nasal and duodenal administration. Also, the permeability enhancing effect of the C-terminal amidated peptide was significantly promoted by the fructose polymer, levan. C-terminal amidated peptide together with the addition of levan may be promising as a tight junction modulated permeation enhancer, and allow the development of the mucosal drug delivery of low bioavailability therapeutic agents.

목차

서 론(Introduction)

실험방법(Experimental Methods)

결과 및 고찰(Results and Discussion)

결 론(Conclusion)

감사의 말씀(Acknowledgment)

References

키워드

Tight junction modulator C-terminal amidation fructose polymer atenolol