SLCO1B1 T521C가 스타틴에 의한 저밀도지단백 콜레스테롤 감소에 미치는 영향: 체계적 문헌고찰 및 메타분석

• 영문명: Effect of SLCO1B1 T521C on statin-induced reduction in low-density lipoprotein cholesterol: a systematic review and meta-analysis
• 발행기관: 대한약학회
• 저자명: 이영숙(Young Sook Lee) 천부순(Pusoon Chun)
• 간행물 정보: 『약학회지』제62권 제4호(2018년), 247~256쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2018.08.30

영문 초록

Increasing number of studies have examined the effect of SLCO1B1 T521C polymorphism on lipid-lowering efficacy of statin. This study was conducted to clarify the effect of SLCO1B1 T521C on the rate of statin-induced reduction in low-density lipoprotein cholesterol (LDL-C). The databases of PubMed, Embase, Ovid, and Cochrane Library were searched for all published studies from inception to April 2018. Using the Review Manager 5, the pooled estimates of the weighted mean difference (WMD) of the percent changes of LDL-C and corresponding 95% confidence intervals (CIs) were calculated. A total of 17 cohort studies were included in this meta-analysis. The percent reduction in LDL-C was slightly higher in the statin users carrying 521TT than in the users carrying 521CC (WMD: 2.41; 95% CI: 0.15, 4.67; p=0.04). Sim-ilarly, the carriers of 521TC achieved slightly higher reduction in LDL-C than the carriers of 521CC (WMD: 2.07; 95% CI: 0.79, 3.35; p=0.002). However, no significant difference in percent reduction was found between the carriers and non-carriers of the 521C allele (TC+CC vs TT, WMD: 0.87; 95% CI: -0.67, 2.41; p=0.27). These results imply that the SLCO1B1 T521C polymorphism has little or no effect on the rate of reduction in LDL-C following statin therapy.

목차

서 론 (Introduction)

연구 방법 (Research Methods)

결 과 (Results)

고찰 (Discussion)

결 론 (Conclusion)

키워드

SLCO1B1 T521C polymorphism statin low-density lipoprotein cholesterol reduction rate