인간 기도 상피세포에서 MUC5AC 뮤신 유전자 발현 및 생성에 대한 코니페린 등 흰털오가피 유래 천연물의 영향

• 영문명: Effects of natural products derived from Acanthopanax divaricatus var. albeofructus including coniferin on gene expression and production of MUC5AC mucin from human airway epithelial cells
• 발행기관: 대한약학회
• 저자명: 이현재(Hyun Jae Lee)
• 간행물 정보: 『약학회지』제62권 제2호(2018년), 118~125쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2018.03.30

국문 초록

We investigated whether coniferin, tortoside A, eleutheroside E or salvadoraside derived from Acanthopanax divaricatus var. albeofructus affects airway MUC5AC mucin gene expression and production induced by epidermal growth factor(EGF) from NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with EGF for 24h. The four compounds inhibited the gene expression and production of MUC5AC mucin from NCI-H292 cells. This result suggests that the four compounds can inhibit the production and gene expression of mucin induced by EGF, through directly acting on airway epithelial cells.

목차

서론 (Introduction)

실험 방법 (Experimental Methods)

실험 결과 (Results)

고 찰 (Discussion)

결 론 (Conclusion)

키워드

airway mucin coniferin